CFCs (fully halogenated hydrocarbon containing chorine and fluorine atoms in their molecule): these chemicals were for the first time synthesized in twenties of the last century. They found application because of their chemical stability and other useful characteristics: they are non-toxic, inflammable, they do not affect living organisms and are not carcinogen.

The most common ozone depleting substances are chlorofluorocarbons (CFCs) used for refrigeration, air-conditioning, blowing foams, solvents, sterilants and aerosol propellants. When released into the atmosphere these CFCs are broken apart by solar radiation, thus releasing a chlorine atom which reacts with the ozone molecule.

Ordinance for banning of the import of used refrigerators, freezers, and other cooling devices and import of the ODSs (OJ of the Republic of Macedonia, no. 87/2006): As of 1 January 2007 the import of the refrigeration (refrigerators, freezers, etc) containing Annex A Group I substances is banned. As of 1 January 2009 the import of the Annex A Group I ODSs is banned.